4.6 Article

Acid-responsive nanospheres from an asparagine-derived amphiphile

Journal

RSC ADVANCES
Volume 5, Issue 12, Pages 8585-8590

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra11884g

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Funding

  1. San Antonio Life Sciences Institute (SALSI)
  2. National Center for Research Resources [5 G12RR013646-12]
  3. NIH National Institute on Minority Health and Health Disparities [G12MD007591]

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We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.

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