Journal
SCIENCE
Volume 333, Issue 6048, Pages 1458-1462Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1207121
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Funding
- Autism
- Human Frontier Science Program
- Jane Coffins Child postdoctoral fellowship
- NIH [2R37NS040929]
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How to build and maintain a reliable yet flexible circuit is a fundamental question in neurobiology. The nervous system has the capacity for undergoing modifications to adapt to the changing environment while maintaining its stability through compensatory mechanisms, such as synaptic homeostasis. Here, we describe our findings in the Drosophila larval visual system, where the variation of sensory inputs induced substantial structural plasticity in dendritic arbors of the postsynaptic neuron and concomitant changes to its physiological output. Furthermore, our genetic analyses have identified the cyclic adenosine monophosphate (cAMP) pathway and a previously uncharacterized cell surface molecule as critical components in regulating experience-dependent modification of the postsynaptic dendrite morphology in Drosophila.
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