Journal
SCIENCE
Volume 329, Issue 5991, Pages 562-565Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1191880
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Funding
- Japan Society for the Promotion of Science (JSPS) [21390534]
- NIH, NIDCR
- Grants-in-Aid for Scientific Research [21390534] Funding Source: KAKEN
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During embryonic development, many organs form by extensive branching of epithelia through the formation of clefts and buds. In cleft formation, buds are delineated by the conversion of epithelial cell-cell adhesions to cell-matrix adhesions, but the mechanisms of cleft formation are not clear. We have identified Btbd7 as a dynamic regulator of branching morphogenesis. Btbd7 provides a mechanistic link between the extracellular matrix and cleft propagation through its highly focal expression leading to local regulation of Snail2 (Slug), E-cadherin, and epithelial cell motility. Inhibition experiments show that Btbd7 is required for branching of embryonic mammalian salivary glands and lungs. Hence, Btbd7 is a regulatory gene that promotes epithelial tissue remodeling and formation of branched organs.
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