Journal
SCIENCE
Volume 328, Issue 5976, Pages 357-360Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1186430
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Funding
- NIH [AI058113, AI057157, GM080209]
- Achievement Rewards for College Scientists Foundation
- Skaggs Institute for Chemical Biology
- National Cancer Institute [Y1-CO-1020]
- National Institute of General Medical Sciences [Y1-GM-1104]
- U.S. Department of Energy, Basic Energy Sciences, Office of Science [DE-AC02-06CH11357]
- Pediatric Infectious Diseases Society Fellowship
- MedImmune
- AstraZeneca
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The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.
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