Journal
SCIENCE
Volume 327, Issue 5963, Pages 348-351Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1183090
Keywords
-
Categories
Funding
- Life Sciences Research Foundation
- Helen Hay Whitney Foundation
- NIH [MH086867, MH085205]
- Stanley Medical Research Institute
- Harvard Stem Cell Institute
- McKnight Endowment Fund for Neuroscience
Ask authors/readers for more resources
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish. We found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors. Behavioral profiling revealed conserved functions of psychotropic molecules and predicted the mechanisms of action of poorly characterized compounds. In addition, behavioral profiling implicated new factors such as ether-a-go-go-related gene ( ERG) potassium channels and immunomodulators in the control of rest and locomotor activity. These results demonstrate the power of high-throughput behavioral profiling in zebrafish to discover and characterize psychotropic drugs and to dissect the pharmacology of complex behaviors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available