Journal
SCIENCE
Volume 330, Issue 6001, Pages 197-U50Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1194238
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Funding
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1019626] Funding Source: National Science Foundation
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Bacterial biofilms are structured multicellular communities involved in a broad range of infections. Knowing how free-swimming bacteria adapt their motility mechanisms near surfaces is crucial for understanding the transition between planktonic and biofilm phenotypes. By translating microscopy movies into searchable databases of bacterial behavior, we identified fundamental type IV pili-driven mechanisms for Pseudomonas aeruginosa surface motility involved in distinct foraging strategies. Bacteria stood upright and walked with trajectories optimized for two-dimensional surface exploration. Vertical orientation facilitated surface detachment and could influence biofilm morphology.
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