Journal
SCIENCE
Volume 329, Issue 5997, Pages 1353-1355Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1190689
Keywords
-
Categories
Funding
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH
- Conselho Nacionale de Desenvolvimento Cientifico e Tecnologico
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior Brazilian government agencies
Ask authors/readers for more resources
Mosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available