Journal
SCIENCE
Volume 330, Issue 6004, Pages 628-629Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1191044
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Funding
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0950128] Funding Source: National Science Foundation
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Paramutation refers to the process by which homologous DNA sequences communicate in trans to establish meiotically heritable expression states. Although mechanisms are unknown, current data are consistent with the hypothesis that the establishment and heritable transmission of specific chromatin states underlies paramutation. Transcribed, noncoding tandem repeats and proteins implicated in RNA-directed transcriptional silencing in plants and yeast are required for paramutation, yet the specific molecules mediating heritable silencing remain to be determined.
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