Journal
SCIENCE
Volume 327, Issue 5969, Pages 1126-1129Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1184096
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Funding
- Helen Hay Whitney Foundation
- National Institutes of Health
- Netherlands Organisation for Scientific Research (NWO)
- Hoover Circle fund
- Howard Hughes Medical Institute
- U.S. Department of Energy [DE-FG03-90ER20010]
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The nitrogen-fixing symbiosis between Sinorhizobium meliloti and its leguminous host plant Medicago truncatula occurs in a specialized root organ called the nodule. Bacteria that are released into plant cells are surrounded by a unique plant membrane compartment termed a symbiosome. We found that in the symbiosis-defective dnf1 mutant of M. truncatula, bacteroid and symbiosome development are blocked. We identified the DNF1 gene as encoding a subunit of a signal peptidase complex that is highly expressed in nodules. By analyzing data from whole-genome expression analysis, we propose that correct symbiosome development in M. truncatula requires the orderly secretion of protein constituents through coordinated up-regulation of a nodule-specific pathway exemplified by DNF1.
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