Journal
SCIENCE
Volume 328, Issue 5984, Pages 1412-1415Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1188160
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Funding
- Deutsche Forschungsgemeinschaft [SFB 654, KO 2067/1-2]
- Faculty of Medicine, University of Kiel, Germany
- Else Kroner-Fresenius-Stiftung
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A critical role in place learning has been attributed to place cells within the cornu ammonis 1 (CA1) sector of the hippocampus in rodents. The role of CA1 cells in the human hippocampus with regard to place learning remains elusive. Using a virtual Morris water maze, we investigated patients with acute transient global amnesia (TGA), a rare self-limiting dysfunction of the hippocampal system. Fourteen individuals with selective and focal lesions in the CA1 sector of the hippocampus showed a profound impairment in place learning. The size of the lesions and the duration of the TGA correlated with the deficit in the performance.
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