Journal
SCIENCE
Volume 328, Issue 5974, Pages 85-89Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1185244
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Funding
- Science Foundation Ireland [06/IN.1/B851]
- European Union (EU) [Transistor-MRTNCT-2004-512285, IRG-224864]
- NSF [2010-0520193]
- Spanish Ministerio de Ciencia e Innovacion [BFU2008-04251, BIO2006-10994, BIO2009-10876]
- Millard and Muriel Jacobs Laboratory at Caltech
- Netherlands Proteomics Centre
- CBSG
- Horizon [93519020]
- CRAG
- Science Foundation Ireland (SFI) [06/IN.1/B851] Funding Source: Science Foundation Ireland (SFI)
- ICREA Funding Source: Custom
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The MADS-domain transcription factor APETALA1 (AP1) is a key regulator of Arabidopsis flower development. To understand the molecular mechanisms underlying AP1 function, we identified its target genes during floral initiation using a combination of gene expression profiling and genome-wide binding studies. Many of its targets encode transcriptional regulators, including known floral repressors. The latter genes are down-regulated by AP1, suggesting that it initiates floral development by abrogating the inhibitory effects of these genes. Although AP1 acts predominantly as a transcriptional repressor during the earliest stages of flower development, at more advanced stages it also activates regulatory genes required for floral organ formation, indicating a dynamic mode of action. Our results further imply that AP1 orchestrates floral initiation by integrating growth, patterning, and hormonal pathways.
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