Journal
SCIENCE
Volume 325, Issue 5944, Pages 1128-1131Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1176950
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Funding
- National Human Genome Research Institute Centers of Excellence in Genomic Science
- Personal Genome Project
- Bill and Melinda Gates Foundation
- Harvard Biophysics Program
- Hartmann Foundation
- Det Kongelige Danske Videnskabernes Selskab
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To understand the process by which antibiotic resistance genes are acquired by human pathogens, we functionally characterized the resistance reservoir in the microbial flora of healthy individuals. Most of the resistance genes we identified using culture-independent sampling have not been previously identified and are evolutionarily distant from known resistance genes. By contrast, nearly half of the resistance genes we identified in cultured aerobic gut isolates (a small subset of the gut microbiome) are identical to resistance genes harbored by major pathogens. The immense diversity of resistance genes in the human microbiome could contribute to future emergence of antibiotic resistance in human pathogens.
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