Journal
SCIENCE
Volume 323, Issue 5921, Pages 1593-1597Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1169975
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Funding
- Biotechnology and Biological Sciences Research Council [Industrial Case Award]
- GlaxoSmithKline [Industrial Case Award]
- Royal Society [University Research Fellowship]
- [Next Generation Fellowship]
- EPSRC [EP/D074487/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D074487/1] Funding Source: researchfish
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For over a century, chemical transformations of benzene derivatives have been guided by the high selectivity for electrophilic attack at the ortho/para positions in electron-rich substrates and at the meta position in electron-deficient molecules. We have developed a copper-catalyzed arylation reaction that, in contrast, selectively substitutes phenyl electrophiles at the aromatic carbon-hydrogen sites meta to an amido substituent. This previously elusive class of transformation is applicable to a broad range of aromatic compounds.
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