Journal
SCIENCE
Volume 323, Issue 5922, Pages 1708-1711Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1168877
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Funding
- University of York
- White-Rose Health Innovation Partnership
- Engineering and Physical Sciences Research Council
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Spanish Ministry of Education and Science [CSD 2007-00006]
- EPSRC [EP/F022530/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F022530/1] Funding Source: researchfish
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The sensitivity of both nuclear magnetic resonance spectroscopy and magnetic resonance imaging is very low because the detected signal strength depends on the small population difference between spin states even in high magnetic fields. Hyperpolarization methods can be used to increase this difference and thereby enhance signal strength. This has been achieved previously by incorporating the molecular spin singlet para-hydrogen into hydrogenation reaction products. We show here that a metal complex can facilitate the reversible interaction of para-hydrogen with a suitable organic substrate such that up to an 800-fold increase in proton, carbon, and nitrogen signal strengths are seen for the substrate without its hydrogenation. These polarized signals can be selectively detected when combined with methods that suppress background signals.
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