Journal
SCIENCE
Volume 326, Issue 5957, Pages 1212-1216Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1176488
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Funding
- Wellcome Trust
- MRC and a Lister Institute Prize Fellowship
- Medical Research Council [MC_U105178790, G0501592] Funding Source: researchfish
- MRC [G0501592, MC_U105178790] Funding Source: UKRI
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Subcellular localization of messenger RNAs (mRNAs) can give precise control over where protein products are synthesized and operate. However, just 10 years ago many in the broader cell biology community would have considered this a specialized mechanism restricted to a very small fraction of transcripts. Since then, it has become clear that subcellular targeting of mRNAs is prevalent, and there is mounting evidence for central roles for this process in many cellular events. Here, we review current knowledge of the mechanisms and functions of mRNA localization in animal cells.
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