Journal
SCIENCE
Volume 326, Issue 5952, Pages 585-589Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1179052
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Funding
- Whittemore Peterson Institute
- Whittemore Family foundation
- National Cancer Institute (NCI)
- NIH [HHSN26120080001E]
- NCI/ NIH [CA104943]
- U. S. DoD Prostate Cancer Research Program [W81XWH-07-1338]
- V Foundation for Cancer Research
- Charlotte Geyer Foundation
- Mal and Lea Bank
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Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimated to affect 17 million people worldwide. Studying peripheral blood mononuclear cells (PBMCs) from CFS patients, we identified DNA from a human gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), in 68 of 101 patients (67%) as compared to 8 of 218 (3.7%) healthy controls. Cell culture experiments revealed that patient-derived XMRV is infectious and that both cell-associated and cell-free transmission of the virus are possible. Secondary viral infections were established in uninfected primary lymphocytes and indicator cell lines after their exposure to activated PBMCs, B cells, T cells, or plasma derived from CFS patients. These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS.
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