Journal
SCIENCE
Volume 324, Issue 5928, Pages 784-787Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1169430
Keywords
-
Categories
Funding
- Biotechnology and Biological Science Research Council [BB/D00456X/1]
- Gatsby Charitable foundation
- Biotechnology and Biological Sciences Research Council [BB/D00456X/1] Funding Source: researchfish
Ask authors/readers for more resources
Plant pathogenic bacteria secrete effector proteins that attack the host signaling machinery to suppress immunity. Effectors can be recognized by hosts leading to immunity. One such effector is AvrPtoB of Pseudomonas syringae, which degrades host protein kinases, such as tomato Fen, through an E3 ligase domain. Pto kinase, which is highly related to Fen, recognizes AvrPtoB in conjunction with the resistance protein Prf. Here we show that Pto is resistant to AvrPtoB-mediated degradation because it inactivates the E3 ligase domain. AvrPtoB ubiquitinated Fen within the catalytic cleft, leading to its breakdown and loss of the associated Prf protein. Pto avoids this by phosphorylating and inactivating the AvrPtoB E3 domain. Thus, inactivation of a pathogen virulence molecule is one mechanism by which plants resist disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available