Journal
SCIENCE
Volume 323, Issue 5922, Pages 1729-1733Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1169381
Keywords
-
Categories
Funding
- Swiss National Science Foundation
- Swiss 3R Foundation
- U.S. NIH [AI 067027, HL 055936]
Ask authors/readers for more resources
To generate efficient vaccines and cures for Mycobacterium tuberculosis, we need a far better understanding of its modes of infection, persistence, and spreading. Host cell entry and the establishment of a replication niche are well understood, but little is known about how tubercular mycobacteria exit host cells and disseminate the infection. Using the social amoeba Dictyostelium as a genetically tractable host for pathogenic mycobacteria, we discovered that M. tuberculosis and M. marinum, but not M. avium, are ejected from the cell through an actin-based structure, the ejectosome. This conserved nonlytic spreading mechanism requires a cytoskeleton regulator from the host and an intact mycobacterial ESX-1 secretion system. This insight offers new directions for research into the spreading of tubercular mycobacteria infections in mammalian cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available