Journal
SCIENCE
Volume 324, Issue 5923, Pages 85-89Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1165620
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Funding
- Biotechnology and Biological Sciences Research Council
- SRIF 2 award
- fellowships from the Royal Commission
- Engineering and Physical Sciences Research Council
- Royal Academy of Engineering
- RC-UK Fellowship
- Biotechnology and Biological Sciences Research Council [BB/F008228/1] Funding Source: researchfish
- BBSRC [BB/F008228/1] Funding Source: UKRI
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The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist Adam, which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.
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