Journal
SCIENCE
Volume 327, Issue 5961, Pages 64-67Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1181799
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Funding
- NHGRI NIH HHS [R21 HG004770-01, R21 HG004770] Funding Source: Medline
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R21HG004770] Funding Source: NIH RePORTER
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We report the fabrication of devices in which one single-walled carbon nanotube spans a barrier between two fluid reservoirs, enabling direct electrical measurement of ion transport through the tube. A fraction of the tubes pass anomalously high ionic currents. Electrophoretic transport of small single-stranded DNA oligomers through these tubes is marked by large transient increases in ion current and was confirmed by polymerase chain reaction analysis. Each current pulse contains about 10(7) charges, an enormous amplification of the translocated charge. Carbon nanotubes simplify the construction of nanopores, permit new types of electrical measurements, and may open avenues for control of DNA translocation.
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