Journal
SCIENCE
Volume 325, Issue 5948, Pages 1661-1664Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1178239
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Funding
- NIH [GM46059]
- Merck
- Nippon Chemical
- Boehringer Ingelheim
- BASF
- Singapore-MIT Alliance
- Spanish Ministerio de Educacion y Ciencia
- Alexander von Humboldt Foundation
- NSF [CHE 9808061, DBI 9729592]
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Despite increasing pharmaceutical importance, fluorinated aromatic organic molecules remain difficult to synthesize. Present methods require either harsh reaction conditions or highly specialized reagents, making the preparation of complex fluoroarenes challenging. Thus, the development of general methods for their preparation that overcome the limitations of those techniques currently in use is of great interest. We have prepared [LPd(II)Ar(F)] complexes, where L is a biaryl monophosphine ligand and Ar is an aryl group, and identified conditions under which reductive elimination occurs to form an Ar-F bond. On the basis of these results, we have developed a catalytic process that converts aryl bromides and aryl triflates into the corresponding fluorinated arenes by using simple fluoride salts. We expect this method to allow the introduction of fluorine atoms into advanced, highly functionalized intermediates.
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