Journal
SCIENCE
Volume 326, Issue 5949, Pages 134-136Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1177531
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Funding
- Wellcome Trust
- European Union's Framework Programme F7 [223241]
- European Molecular Biology Organization
- University of Oxford John Fell Fund
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Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito's innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.
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