Journal
RSC ADVANCES
Volume 5, Issue 1, Pages 301-307Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra13266a
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Funding
- Australian Research Council Discovery Project [DP130103131]
- NHMRC Career Development Fellowship [APP1050684]
- Alfred Deakin Research Fellowship
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Hydrogels formed by the self-assembly of peptides are promising biomaterials. The bioactive and biocompatible molecule Fmoc-FRGDF has been shown to be an efficient hydrogelator via a pi-beta self-assembly mechanism. Herein, we show that the mechanical properties and morphology of Fmoc-FRGDF hydrogels can be effectively and easily manipulated by tuning both the final ionic strength and the rate of pH change. The increase of ionic strength, and consequent increase in rate of gelation and stiffness, does not interfere with the underlying pi-beta assembly of this Fmoc-protected peptide. However, by tuning the changing rate of the system's pH through the use of glucono-delta-lactone to forma hydrogel, as opposed to the previously reported HCl methodology, the morphology (nano- and microscale) of the scaffold can be manipulated.
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