Journal
RSC ADVANCES
Volume 5, Issue 49, Pages 38810-38817Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra02933c
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Funding
- Foundation of the National Natural Science Foundation of China [21406094, 21201086]
- Foundation of Jiangsu University [04JDG048]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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The objective of the study is to describe a new approach of combining quantum dots into chitosan as an anti-cancer drug carrier. Novel chitosan-ZnSe/ZnS (CS-ZnSe/ZnS) nanoparticles were synthesized by a one-step ionic gelation technique, with ZnSe/ZnS quantum dots (ZnSe/ZnS QDs) as cross-linking agent and for fluorescent labeling. The approach not only avoids the use of emulsifiers and chemical cross-linking agents but also prevents the possibility of damage to drugs. The fluorescent CS-ZnSe/ZnS nanoparticles were about 100-500 nm in size and stable in a physiological environment. Low cytotoxicity was ensured by investigation with mouse lung carcinoma cells. The cell viability remained 99% when the concentration of CS-ZnSe/ZnS nanoparticles increased to 200 mu g mL(-1). In the in vitro drug release experiment, 5-fluorouracil (5-Fu) loaded within CS-ZnSe/ZnS nanoparticles had more preferable sustained-release performance and longer equilibrium time compared with that of the pure 5-Fu. The fluorescent CS-ZnSe/ZnS nanoparticles are expected to be used for biological fluorescent labeling and drug carriers.
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