Journal
SCIENCE
Volume 322, Issue 5906, Pages 1380-1384Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1164147
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- Giovanni Armenise-Harvard Foundation
- Istituto Pasteur- Fondazione Cenci Bolognetti
- Ministero dell'Istruzione
- dell'Universita e della Ricerca ( MIUR)
- Ricerca di Interesse Nazionale
- MIUR Fondo per gli Investimenti della Ricerca di Base European Research Area-Plant Genomics
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Plant growth and development are sustained by meristems. Meristem activity is controlled by auxin and cytokinin, two hormones whose interactions in determining a specific developmental output are still poorly understood. By means of a comprehensive genetic and molecular analysis in Arabidopsis, we show that a primary cytokinin- response transcription factor, ARR1, activates the gene SHY2/IAA3 (SHY2), a repressor of auxin signaling that negatively regulates the PIN auxin transport facilitator genes: thereby, cytokinin causes auxin redistribution, prompting cell differentiation. Conversely, auxin mediates degradation of the SHY2 protein, sustaining PIN activities and cell division. Thus, the cell differentiation and division balance necessary for controlling root meristem size and root growth is the result of the interaction between cytokinin and auxin through a simple regulatory circuit converging on the SHY2 gene.
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