Journal
SCIENCE
Volume 319, Issue 5859, Pages 101-104Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1143808
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Funding
- NIDA NIH HHS [DA017188-01, R01 DA017188] Funding Source: Medline
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In vivo experience can occlude subsequent induction of long- term potentiation and enhance long- term depression of synaptic responses. Although a reduced capacity for synaptic strengthening may function to prevent excessive excitation, such an effect paradoxically implies that continued experience or training should not improve and may even degrade neural representations. In mice, we examined the effect of ongoing whisker stimulation on synaptic strengthening at layer 4-2/3 synapses in the barrel cortex. Although N- methyl- D- aspartate receptors were required to initiate strengthening, they subsequently suppressed further potentiation at these synapses in vitro and in vivo. Despite this transition, synaptic strengthening continued with additional sensory activity but instead required the activation of metabotropic glutamate receptors, suggesting a mechanism by which continued experience can result in increasing synaptic strength over time.
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