Journal
SCIENCE
Volume 322, Issue 5908, Pages 1705-1710Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1159894
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Funding
- Ministere Francais de la Recherche
- Association pour la Recherche contre le Cancer
- ECOS-Comision Nacional de Investigacion Cientifica y Technologica
- Gobierno de Chile [CO3S01]
- Institut Curie and Inserm
- ARC, Fondecyt (Chile) [1060834, 1060253]
- Agence Nationale pour la Recherche [ANR-06-PCVI-0010]
- Human Frontiers Science Program [RGY53/2007]
- Agence Nationale de la Recherche (ANR) [ANR-06-PCVI-0010] Funding Source: Agence Nationale de la Recherche (ANR)
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Dendritic cells ( DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II- associated invariant chain (li or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild- type DCs alternate between high and low motility, whereas li-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by li depended on the actin- based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.
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