Journal
SCIENCE
Volume 320, Issue 5877, Pages 789-792Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1154413
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In the bacterium Escherichia coli, the Min proteins oscillate between the cell poles to select the cell center as division site. This dynamic pattern has been proposed to arise by self- organization of these proteins, and several models have suggested a reaction- diffusion type mechanism. Here, we found that the Min proteins spontaneously formed planar surface waves on a flat membrane in vitro. The formation and maintenance of these patterns, which extended for hundreds of micrometers, required adenosine 5 '- triphosphate (ATP), and they persisted for hours. We present a reaction- diffusion model of the MinD and MinE dynamics that accounts for our experimental observations and also captures the in vivo oscillations.
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