Journal
SCIENCE
Volume 322, Issue 5902, Pages 703-709Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1160058
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Funding
- Howard Hughes Medical Institute
- David Koch Research Award
- Curt W. and Kathy Marble Cancer Research Fund
- David Koch Graduate Fellowship
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Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes. In all four trisomic lines, proliferation was impaired and metabolic properties were altered. Immortalization, the acquisition of the ability to proliferate indefinitely, was also affected by the presence of an additional copy of certain chromosomes. Our data indicate that aneuploidy decreases not only organismal but also cellular fitness and elicits traits that are shared between different aneuploid cells.
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