Journal
SCIENCE
Volume 319, Issue 5862, Pages 482-484Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1151582
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Funding
- NIDDK NIH HHS [R90 DK071511, 5 R90 DK071511-01] Funding Source: Medline
- NIGMS NIH HHS [R01-GM068957, R01 GM068957, R01 GM068957-06, R01 GM068957-05] Funding Source: Medline
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The propagation of information through signaling cascades spans a wide range of time scales, including the rapid ligand- receptor interaction and the much slower response of downstream gene expression. To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo- adaptation pathway of Saccharomyces cerevisiae. We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo- adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli.
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