Journal
SCIENCE
Volume 321, Issue 5892, Pages 1088-1091Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1158699
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Time's Arrow and Biosignaling
- Precursory Research for Embryonic Science and Technology
- Japan Science and Technology Agency
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The centromere is essential for the inheritance of genetic information on eukaryotic chromosomes. Epigenetic regulation of centromere identity has been implicated in genome stability, karyotype evolution, and speciation. However, little is known regarding the manner in which centromere dysfunction affects the chromosomal architectures. Here we show that in the fission yeast Schizosaccharomyces pombe, the conditional deletion of the centromere produces survivors that carry either a neocentromere- acquired chromosome at the subtelomeric region or an acentric chromosome rescued by intertelomere fusion with either of the remaining chromosomes. The ratio of neocentromere formation to telomere fusion is considerably decreased by the inactivation of genes involved in RNA interference- dependent heterochromatin formation. By affecting the modes of chromosomal reorganization, the genomic distribution of heterochromatin may influence the fate of karyotype evolution.
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