Journal
SCIENCE
Volume 322, Issue 5903, Pages 896-900Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1159277
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Categories
Funding
- NIH [R01 NS051820, NS045264, NS34950, R01 GM073644]
- Javits Award
- United States-Israel Binational Science Foundation [200596]
- NSF Frontiers in Biological Research [EF04-5852]
- U.S. Department of Agriculture [AG2003-35302-13490]
- Burroughs Wellcome Fund Innovation Award
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What genes and regulatory sequences contribute to the organization and functioning of neural circuits and molecular pathways in the brain that support social behavior? How does social experience interact with information in the genome to modulate brain activity? Here, we address these questions by highlighting progress that has been made in identifying and understanding two key vectors of influence that link genes, the brain, and social behavior: (i) Social information alters gene expression in the brain to influence behavior, and (ii) genetic variation influences brain function and social behavior. We also discuss how evolutionary changes in genomic elements influence social behavior and outline prospects for a systems biology of social behavior.
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