Journal
SCIENCE
Volume 321, Issue 5887, Pages 414-417Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1153276
Keywords
-
Categories
Funding
- NCRR NIH HHS [P41 RR014075, P41 RR014075-13, P41RR14075] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000790, R01 EB000790-05] Funding Source: Medline
Ask authors/readers for more resources
The frontal eye field (FEF) is one of several cortical regions thought to modulate sensory inputs. Moreover, several hypotheses suggest that the FEF can only modulate early visual areas in the presence of a visual stimulus. To test for bottom-up gating of frontal signals, we microstimulated subregions in the FEF of two monkeys and measured the effects throughout the brain with functional magnetic resonance imaging. The activity of higher-order visual areas was strongly modulated by FEF stimulation, independent of visual stimulation. In contrast, FEF stimulation induced a topographically specific pattern of enhancement and suppression in early visual areas, but only in the presence of a visual stimulus. Modulation strength depended on stimulus contrast and on the presence of distractors. We conclude that bottom-up activation is needed to enable top-down modulation of early visual cortex and that stimulus saliency determines the strength of this modulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available