Journal
SCIENCE
Volume 322, Issue 5908, Pages 1710-1713Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1165322
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Funding
- Wellcome Trust [083639/Z/07/Z]
- Edward Penley Abraham Trust
- MRC
- Wellcome Trust [083639/Z/07/Z] Funding Source: Wellcome Trust
- MRC [MC_U105184308] Funding Source: UKRI
- Medical Research Council [MC_U105184308] Funding Source: researchfish
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Archaea are prokaryotic organisms that lack endomembrane structures. However, a number of hyperthermophilic members of the Kingdom Crenarchaea, including members of the Sulfolobus genus, encode homologs of the eukaryotic endosomal sorting system components Vps4 and ESCRT- III ( endosomal sorting complex required for transport- III). We found that Sulfolobus ESCRT- III and Vps4 homologs underwent regulation of their expression during the cell cycle. The proteins interacted and we established the structural basis of this interaction. Furthermore, these proteins specifically localized to the mid- cell during cell division. Overexpression of a catalytically inactive mutant Vps4 in Sulfolobus resulted in the accumulation of enlarged cells, indicative of failed cell division. Thus, the archaeal ESCRT system plays a key role in cell division.
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