Journal
SCIENCE
Volume 322, Issue 5901, Pages 587-590Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1162667
Keywords
-
Categories
Funding
- U.S. Public Health Service [MH18501]
- Research Scientist Award [DA00074]
- Canadian Institutes of Health Research
Ask authors/readers for more resources
Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues, Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation. These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available