Journal
SCIENCE
Volume 322, Issue 5898, Pages 92-96Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1159572
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Funding
- Biotechnology and Biological Sciences Research Council
- Newcastle University
- Australian Research Council
- University of Newcastle (Australia)
- European Union NOE [LSHG-CT-2004-502828]
- Dutch Ministry of Economic Affairs [BSIK 03036]
- BBSRC
- Glaxo Wellcome
- SmithKline Beecham
- BBSRC [BB/F001533/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D000521/1, BB/F001533/1] Funding Source: researchfish
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A commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of stress- responsive genes. Stress signals can be integrated by a multiprotein signaling hub that responds to various signals to effect a single outcome. We obtained a medium- resolution cryo- electron microscopy reconstruction of the 1.8- megadalton stressosome from Bacillus subtilis. Fitting known crystal structures of components into this reconstruction gave a pseudoatomic structure, which had a virus capsid- like core with sensory extensions. We suggest that the different sensory extensions respond to different signals, whereas the conserved domains in the core integrate the varied signals. The architecture of the stressosome provides the potential for cooperativity, suggesting that the response could be tuned dependent on the magnitude of chemophysical insult.
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