Journal
SCIENCE
Volume 322, Issue 5906, Pages 1384-1387Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1164216
Keywords
-
Categories
Funding
- NIH [GM069462]
- University of Arizona NSF- IGERT ( Integrative Graduate Education and Research Traineeships) Program in Genomics
- Graduate Training in Biochemistry and Molecular Biology
Ask authors/readers for more resources
Polytene chromosome structure is a characteristic of some polyploid cells where several to thousands of chromatids are closely associated with perfect alignment of homologous DNA sequences. Here, we show that Drosophila condensin II promotes disassembly of polytene structure into chromosomal components. Condensin II also negatively regulates transvection, a process whereby certain alleles are influenced transcriptionally via interallelic physical associations. We propose that condensin II restricts trans- chromosomal interactions that affect transcription through its ability to spatially separate aligned interphase chromosomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available