Journal
SCIENCE
Volume 322, Issue 5907, Pages 1498-1501Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1162782
Keywords
-
Categories
Funding
- Medical Research Council [G0500220, G0300415] Funding Source: researchfish
- MRC [G0300415, G0500220] Funding Source: UKRI
- Medical Research Council [G0300415, G0500220] Funding Source: Medline
Ask authors/readers for more resources
The development of individual organs in animal embryos involves the formation of tissue- specific stem cells that sustain cell renewal of their own tissue for the lifetime of the organism. Although details of their origin are not always known, tissue- specific stem cells usually share the expression of key transcription factors with cells of the embryonic rudiment from which they arise, and are probably in a similar developmental state. On the other hand, the isolation of pluripotent stem cells from the postnatal organism has encouraged the formulation of models of embryonic and postnatal development that are at variance with the conventional ones. Possible explanations for the existence of such cells, and the issue of whether they also exist in vivo, are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available