Journal
SCIENCE
Volume 320, Issue 5879, Pages 1074-1077Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1153277
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Funding
- NHLBI NIH HHS [P50 HL060292-08, HL07901-08, P50 HL060292, T32 HL007901, HL60292] Funding Source: Medline
- NINDS NIH HHS [R01 NS033987-11, R01 NS033987, R01 NS051609, NS33987, F32 NS057119, NS057119, NS051609] Funding Source: Medline
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When food is plentiful, circadian rhythms of animals are powerfully entrained by the light- dark cycle. However, if animals have access to food only during their normal sleep cycle, they will shift most of their circadian rhythms to match the food availability. We studied the basis for entrainment of circadian rhythms by food and light in mice with targeted disruption of the clock gene Bmal1, which lack circadian rhythmicity. Injection of a viral vector containing the Bmal1 gene into the suprachiasmatic nuclei of the hypothalamus restored light- entrainable, but not food- entrainable, circadian rhythms. In contrast, restoration of the Bmal1 gene only in the dorsomedial hypothalamic nucleus restored the ability of animals to entrain to food but not to light. These results demonstrate that the dorsomedial hypothalamus contains a Bmal1- based oscillator that can drive food entrainment of circadian rhythms.
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