Journal
SCHIZOPHRENIA RESEARCH
Volume 152, Issue 2-3, Pages 333-338Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2013.11.032
Keywords
Cortical thickness; FreeSurfer; Local gyrification index; Magnetic resonance imaging
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Funding
- East Norway Health Authority [2005-135]
- Norwegian Research Council [160181/V50, 204966/F20, 190311]
- Swiss National Science Foundation [3200-063135.00/1, 3232-063134.00/1, PP0033-102864, 32473B-121996, 51AU40_125759]
- National Center of Competence in Research (NCCR) SYNAPSY - The Synaptic Bases of Mental Diseases
- Swedish Research Council [2006-2992, 2006-986, 2008-2167]
- Stockholm County Council
- Karolinska Institutet
- Knut and Alice Wallenberg Foundation
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The cerebral cortex is highly convoluted, and principal folding patterns are determined early in life. Degree of cortical folding in adult life may index aberrations in brain development. Results from previous studies of cortical folding in schizophrenia are inconsistent. Here we investigated cortical folding patterns in the hitherto largest sample of patients with schizophrenia drawn from two independent cohorts. Magnetic resonance imaging scans were acquired from 207 patients and 206 healthy subjects recruited to two separate research projects in Sweden and Norway. Local gyrification index (lGI) was estimated continuously across the cortex using automated methods. Group differences in lGI were analyzed using general linear models. Patients had lower lGI in three large clusters of the cortex with peak differences found in the left precentral gyrus, right middle temporal gyrus, and right precuneus. Similar, although not completely overlapping results were found when the two cohorts were analyzed separately. There were no significant interaction effects between age and diagnosis and gender and diagnosis. The finding of reduced degree of folding in large regions of the cerebral cortex across two independent samples indicates that reduced gyrification is an inherent feature of the brain pathology in schizophrenia. (C) 2013 Elsevier B.V. All rights reserved.
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