Journal
SCHIZOPHRENIA RESEARCH
Volume 150, Issue 1, Pages 157-162Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2013.07.051
Keywords
Glycometabolism parameters; Lipid profiles; Drug-naive; First-episode; Schizophrenia; Healthy controls
Categories
Funding
- Science and Technology Plan Project of Guangdong Province [2009B080701080]
- National Natural Science Foundation of China [81071093]
- National R&D Special Fund for Health Profession [201002003]
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To compare the difference in body mass index (BMI), waist-to-hip ratio (WHR), and glucose and lipid metabolism parameters between drug-naive, first-episode schizophrenia patients and healthy controls matched for age, ethnicity and gender, we conducted a test including BMI, WHR, and fasting glucose and lipid metabolism parameters in both 70 drug-naive, first-episode schizophrenia patients, having not a single day of cumulative exposure to antipsychotic medications and 44 normal healthy controls at baseline. Student's t tests (two tailed) were conducted to examine between group differences. We found that drug-naive first-episode schizophrenia patients had higher insulin, insulin resistance and C-peptide levels, and had lower total cholesterol (TC), high density lipoprotein cholesterol (HDL-c) and apolipoproteinA1 levels. Simultaneously, drug-naive, first-episode schizophrenia patients show a potential tendency of WHR enlargement, although there were no statistically significant differences between groups (mean = 0.82, SD = 0.06, for the patients versus mean = 0.79, SD = 0.06, for the health subjects). These results suggest that drug-naive, first-episode schizophrenia patients do differ from healthy controls in their fasting glycometabolism parameters and lipid profiles, including fasting plasma levels of insulin, C-peptide, TC, HDL-c, and apolipoproteinA1, and patients are more insulin resistant before the onset of antipsychotic medication treatment. (C) 2013 Elsevier B.V. All rights reserved.
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