Journal
SCHIZOPHRENIA RESEARCH
Volume 151, Issue 1-3, Pages 43-47Publisher
ELSEVIER
DOI: 10.1016/j.schres.2013.10.011
Keywords
Schizophrenia; Antipsychotic drugs; Cytokines; Inflammation
Categories
Funding
- Fonds de Recherche du Quebec - Sante (FRQS)
- FRQS
- Centre de recherche de l'Institut Universitaire en Sante Mentale de Montreal
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Objectives: Evidence-based medicine suggests that schizophrenia is associated with an inflammatory syndrome, but the extent to which this syndrome is normalized by antipsychotic treatment has yet to be determined. Methods: A systematic quantitative review of the effects of antipsychotics on peripheral cytokine levels in schizophrenia was performed, using follow-up studies providing in vivo cytokine assessments before and after treatment. Results: We retrieved 23 studies (total of 762 subjects) which showed that antipsychotic treatment significantly increases plasma levels of soluble interleukin-2 receptor and reduces the plasma levels of interleukin-1 beta and interferon-gamma. Conclusions: These results show that antipsychotics produce anti-inflammatory effects in schizophrenia. (C) 2013 Elsevier B.V. All rights reserved.
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