Journal
SCHIZOPHRENIA RESEARCH
Volume 150, Issue 2-3, Pages 356-365Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2013.09.010
Keywords
Psychosis; Schizophrenia; Genetics; Environment; Gene-environment interaction
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Funding
- European Community [HEALTH-F2-2009-241909]
- UK National Institute for Health Research (NIHR) fellowship (PCSKBZA)
- Medical Research Council [MR/J008915/1] Funding Source: researchfish
- National Institute for Health Research [PDF-2010-03-047] Funding Source: researchfish
- MRC [MR/J008915/1] Funding Source: UKRI
- National Institutes of Health Research (NIHR) [PDF-2010-03-047] Funding Source: National Institutes of Health Research (NIHR)
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The relatively high heritability of schizophrenia suggests that genetic factors play an important role in the etiology of the disorder. On the other hand, a number of environmental factors significantly influence its incidence. As few direct genetic effects have been demonstrated, and there is considerable inter-individual heterogeneity in the response to the known environmental factors, interactions between genetic and environmental factors may be important in determining whether an individual develops the disorder. To date, a considerable number of studies of gene-environment interactions (G x E) in schizophrenia have employed a hypothesis-based molecular genetic approach using candidate genes, which have led to a range of different findings. This systematic review aims to summarize the results from molecular genetic candidate studies and to review challenges and opportunities of this approach in psychosis research. Finally, we discuss the potential of future prospects, such as new studies that combine hypothesis-based molecular genetic candidate approaches with agnostic genome-wide association studies in determining schizophrenia risk. (C) 2013 Elsevier B. V. All rights reserved.
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