Journal
SCHIZOPHRENIA RESEARCH
Volume 142, Issue 1-3, Pages 200-205Publisher
ELSEVIER
DOI: 10.1016/j.schres.2012.10.008
Keywords
VRK2; Schizophrenia; Asian populations; MRI; Brain imaging analysis
Categories
Funding
- National 973 project of China [2011CBA00401]
- National Natural Science Foundation of China [31237068]
- National Medical Research Council Translational and Clinical Research Flagship Program [NMRC/TCR/003/2008]
- German Federal Ministry of Education and Research (BMBF), within National Genome Research Network (NGFN)
- Integrated Genome Research Network (IG) MooDS [01GS08144, 01GS08147]
- Australian NHMRC program [510135]
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Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17x10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.
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