Journal
SCHIZOPHRENIA RESEARCH
Volume 141, Issue 2-3, Pages 262-265Publisher
ELSEVIER
DOI: 10.1016/j.schres.2012.08.027
Keywords
Neuropsychiatric disorder; Single-nucleotide polymorphism; Synapse; Candidate gene; GABA
Categories
Funding
- Integrated Genome Research Network (IG) MooDS [01GS08144, 01GS08147]
- IZKF, Medical School, Jena University Hospital
- German Federal Ministry of Education and Research (BMBF), within German National Genome Research Network plus (NGFNplus)
- EU
- German Research Foundation [GRK 793]
- [U01 HL089856]
- [R01 MH087590]
- [R01 MH081862]
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Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value=0.0042, OR=0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.
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