Journal
RSC ADVANCES
Volume 5, Issue 100, Pages 82208-82214Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra18036h
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- CSIR, New Delhi
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An efficient, cost effective and green methodology for ipso nitration in the synthesis of the 3-nitro derivative of 3-carboxy 4-quinolones has been developed by the quantitative use of copper acetate and silver nitrate in water. The observed regioselectivity of nitration is explained by the DFT calculations. Three of these compounds with IC50 values (2.9-3.4 mmol) against Brugia malayi thymidylate kinase may be good antifilarial agents as also evidenced by molecular docking studies.
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