Journal
SCHIZOPHRENIA RESEARCH
Volume 132, Issue 1, Pages 50-53Publisher
ELSEVIER
DOI: 10.1016/j.schres.2011.07.027
Keywords
Schizophrenia; Oxytocin; Psychosis; Social cognition; Theory of Mind; Social perception
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Funding
- Foundation of Hope (FOH) for Research and Treatment of Mental Illness
- National Center for Research Services [UL1RR025747]
- GSK
- Novartis
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Oxytocin has numerous prosocial and antipsychotic-like effects in animals. Prosocial effects of acute intranasal oxytocin administration have also been reported in human subjects. We conducted a randomized, placebo-controlled trial testing the effects of twice daily intranasal oxytocin treatment for 14 days on psychotic symptoms and social cognition in patients with schizophrenia. PANSS scores declined significantly and several social cognition measures improved significantly or nearly significantly in oxytocin (N = 11) but not placebo (N = 9) recipients. Our results suggest that, in addition to reducing classic psychotic symptoms, oxytocin may diminish certain social cognition deficits that are not improved by current antipsychotic medications. (C) 2011 Elsevier B.V. All rights reserved.
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