Journal
SCHIZOPHRENIA RESEARCH
Volume 127, Issue 1-3, Pages 202-214Publisher
ELSEVIER
DOI: 10.1016/j.schres.2010.11.009
Keywords
Auditory verbal hallucinations; Schizophrenia; Resting state; Auditory cortex
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Funding
- CIHR
- EJLB Michael Smith Foundation
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While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenological accounts. (C) 2010 Elsevier B.V. All rights reserved.
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