Journal
SCHIZOPHRENIA RESEARCH
Volume 129, Issue 2-3, Pages 163-168Publisher
ELSEVIER
DOI: 10.1016/j.schres.2011.03.020
Keywords
Surface area; Default Mode Network; Salience Network; Central Executive Network; Schizophrenia
Categories
Funding
- University of Nottingham
- Nottingham Institute of Neuroscience, University of Nottingham
- Medical Research Council UK [79708]
- Lilly Young Investigator Travel Fellowship
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In schizophrenia, morphological changes in the cerebral cortex have been primarily investigated using volumetric or cortical thickness measurements. In healthy subjects, as the brain size increases, the surface area expands disproportionately when compared to the scaling of cortical thickness. In this structural MRI study, we investigated the changes in brain surface area in schizophrenia by constructing relative areal contraction/expansion maps showing group differences in surface area using Freesurfer software in 57 patients and 41 controls. We observed relative areal contraction affecting Default Mode Network, Central Executive Network and Salience Network, in addition to other regions in schizophrenia. We confirmed the surface area reduction across these three large-scale brain networks by undertaking further region-of-interest analysis of surface area. We also observed a significant hemispheric asymmetry in the surface area changes, with the left hemisphere showing a greater reduction in the areal contraction maps. Our findings suggest that a fundamental disturbance in cortical expansion is likely in individuals who develop schizophrenia. (C) 2011 Elsevier B.V. All rights reserved.
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