Journal
SCHIZOPHRENIA RESEARCH
Volume 116, Issue 2-3, Pages 243-251Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2009.08.005
Keywords
SCIP; Cut-off scores; Cognitive impairment; Screening; Schizophrenia; Bipolar disorder
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Funding
- Pfizer Spain
- Departament d'Universitats, Recerca i Societat de la Informacio de la Generalitat de Catalunya [2007FIC00736, 2005SGR00365]
- Ministerio de Educacion y Ciencia de Espana [SEJ2005-09144-C02-02/PSIC]
- Spanish Ministry of Health, Instituto de Salud Carlos III [RETICS RD06/0011]
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Objectives: To demonstrate the ability of the Screen for Cognitive Impairment in Psychiatry (SCIP-S) to discriminate between cognitively-impaired individuals and those with adequate functioning in a sample of schizophrenic and bipolar patients, as well as in a control group. Methods: The SCIP-S, together with a full neuropsychological battery, was administered to three groups: patients with schizophrenia, patients diagnosed with bipolar disorder 1, and controls. The battery scores were used to perform a standardization with respect to the control group and this served to determine the comparison groups (cognitively impaired versus unimpaired) for each of the subtests of the SCIP-S. A full analysis of decision validity was conducted on the basis of receiver operating characteristic curves (sensitivity and specificity, + LR and - LR, PPV and NPV). Results: All the subtests yielded adequate values for sensitivity and specificity with the proposed cut-off points, while the total score of the SCIP (<70) was associated with a sensitivity of 87.9 and specificity of 80.6. Conclusions: The SCIP-S shows adequate decision validity as a screening tool for cognitive deficit in patients diagnosed with schizophrenia or bipolar disorder. (C) 2009 Elsevier B.V. All rights reserved.
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